Publication Summary

Study Area

Burn wounds

Design

Prospective, randomized, controlled study

Study Finds Vomaris™ Bioelectric Technology Significantly Decreased Biofilm in Burn Patients

Chan RK, Nuutila K, et al.; Adv Wound Care (New Rochelle). 2023 Apr 11. doi: 10.1089/ wound.2023.0007. Epub ahead of print.

• Early, short-term treatment with WED significantly decreased biofilm severity in all burn wounds.
• Incidence of opportunistic pathogens such as Ralstonia pickettii and Serratia marcescens was significantly lower in WED-treated wounds compared to SoC.
• WED may result in a therapy that is superior to silver alone.

Study Area

Wound biofilm infection

Design

Pre-clinical porcine mechanistic study

Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing

Barki KG, Das A, Dixith S, et al.; Ann Surg, 2017.

• Tested ability of wireless electroceutical device (WED) to manage bacterial biofilm infection in vivo in porcine chronic wound biofilm infection model inoculated with Pseudomonas aeruginosa and Acinetobacter baumannii.
• WED disrupted existing biofilm infection and prevented biofilm from forming.
• WED repressed genes responsible for quorum sensing, disrupting bacteria’s ability to communicate and form biofilm.

Study Area

Diabetic wounds

Design

Prospective case series

Human Acellular Dermal Matrix Paired with Silver-Zinc Coupled Electroceutical Dressing Results in Rapid Healing of Complicated Diabetic Wounds of Mixed Etiology: A Novel Case Series

Cole W; Wounds. 2016;28(7):241-247.

• Electroceutical wound dressing used in combination with human acellular dermal matrix in three complex cases (conventional care was unable to close wounds in up to two years).
• All three cases healed fully within six weeks with this alternative treatment.

Study Area

WED in conjunction with NPWT

Design

Randomized controlled clinical trial

A Wireless Electroceutical Dressing Lowers Cost of Negative Pressure Wound Therapy

Ghatak PD, Schlanger R, Ganesh K, et al.; Adv Wound Care. 2015;4(5):302-311.

• Thirty (30) chronic wound patients undergoing negative pressure wound therapy (NPWT) were randomized into two arms (control = NPWT standard of care with thrice weekly dressing changes and test
  = wireless electrical device [WED] + NPWT with twice weekly dressing changes).
• WED + NPWT effectively decreased required dressing change frequency thrice to twice weekly without negatively impacting wound healing.
• Cost of care with use of WED + NPWT was significantly lower than NPWT alone (p<0.05).

Study Area

Acute and chronic wounds

Design

Retrospective dual center review of wound healing outcomes

Demonstration of a Microcurrent-Generating Wound Care Device for Wound Healing within a Rehabilitation Center Patient Population

Whitcomb E, Monroe N, Hope-Higman J, et al.; J Am Coll Clin Wound Spec. 2013;4:32-39.

• Evaluated differences in wound healing outcomes when treated with microcurrent-generating wound care device (MCD, n=18) vs. standard of care (SOC, n=20).
• Study population of rehabilitation and long-term care patients with acute and chronic wounds of varied etiology.
• MCD group wounds healed significantly faster (19.78 days) than SOC group (36.25 days) (p=0.036)
• 83.3% of MCD group wounds healed monotonically vs. 50% of SOC group (p=0.018).

Study Area

Skin graft harvest sites

Design

Prospective single center clinical study

The Use of Bioelectric Dressings in Skin Graft Harvest Sites: A Prospective Case Series

Blount AL, Foster S, Rapp DA, et al.; J Burn Care Res. 2012;33(3):354-357.

• Compared acute wound healing after skin grafting (n=13).
• Half of each graft donor site was covered with a standard dressing (control) and half with a bioelectric dressing (test); both were covered with a semi-occlusive dressing.
• One week post-op: significantly greater epithelialization with bioelectric dressing (71.8%) vs. control (46.9%) (p=0.015).
• Blinded evaluator rated bioelectric dressing side visually superior in 92.3% of wounds.